Population Genomics Directed Dissection of Bacterial Pathogens

Our research strategy leverages bacterial genomes from real-world clinical isolates to identify mutations driving key adaptive traits, including antibiotic resistance, transmission, and virulence. We then apply advanced experimental microbiology approaches to dissect the functional consequences of these mutations. By integrating genomic and functional insights, we aim to uncover bacterial processes that can be targeted for the development of novel diagnostics, therapeutics, and public health interventions.