Population Genomics Directed Dissection of Bacterial Pathogens

Our research strategy involves utilizing bacterial genomes from real-world (clinical) isolates to identify mutations underlying evolving traits, such as antibiotic resistance, transmission, and virulence. We then employ cutting-edge experimental microbiology methods to dissect the altered bacterial functions responsible for these evolved traits. Through these endeavors, we aim to uncover bacterial processes that can be targeted for the development of new vaccines, therapeutics, and public health intervention strategies.